Population
Preglomerular microvascular smooth muscle cells from spontaneously hypertensive rats and normotensive…
Comparison
Angiotensin II (Ang II) vs Normotensive Wistar-Kyoto rats cells, and…
Design
Preclinical
Authors
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Indicates heightened Ang II-PLD2 sensitivity in SHR vasculature; hypothesis-generating for human hypertension, does not yet inform therapy.
Angiotensin II induces greater phospholipase D activity via AT1 receptors and PLD2 in preglomerular microvascular smooth muscle cells from spontaneously hypertensive rats, highlighting a potential altered signaling pathway in genetic hypertension.
Andresen et al. (2001) studied this question.
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