Key result
In rat aortic vascular smooth-muscle cells, phospholipase D is coupled to an AT1 receptor and activated by Angiotensin II or Ang-(2-8), but not Ang-(1-7).
Population
Rat aortic vascular smooth-muscle cells (VSMC)
Design
Preclinical
Authors
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Hypothesis-generating for AT1-selective angiotensin signaling in vascular cells; leaves open translation to human disease.
In rat aortic vascular smooth-muscle cells, phospholipase D activation by angiotensin II is mediated through the AT1 receptor.
Freeman et al. (1994) studied Rat aortic vascular smooth-muscle cells. Angiotensin II and Ang-(2-8) vs. Ang-(1-7) and receptor antagonists was evaluated on Diacylglycerol (DAG) accumulation and phosphatidylethanol (PEt) production. In rat aortic vascular smooth-muscle cells, phospholipase D is coupled to an AT1 receptor and activated by Angiotensin II or Ang-(2-8), but not Ang-(1-7).
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