Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 4, 1993FEBS Letters

A role for protein kinase C‐ϵ in angiotensin II stimulation of phospholipase D in rat renal mesangial cells

View Full Paper
Ask AI
Bookmark
Share

Population

Rat renal mesangial cells

Design

Preclinical

Authors

JPJosef PfeilschifterGoethe University FrankfurtAHAndrea HuwilerUniversity Hospital of Bern

Discussion

Loading...

Member takes

Overview

Preclinical findings only; leaves open PKC-epsilon as a potential target in angiotensin II–PLD signaling.

Structured PICO

P
Population
Rat renal mesangial cells
I
Intervention
Angiotensin II stimulation, with various modulators of Ca2+ and PKC (A23187, thapsigargin, quin 2, phorbol esters, calphostin C)
O
Outcome
Phosphatidylcholine-hydrolyzing phospholipase D (PLD) activity (measured by phosphatidylethanol formation)surrogate

Angiotensin II stimulation of phospholipase D in rat renal mesangial cells involves the PKC-epsilon isoenzyme.

Cite This Study

Pfeilschifter et al. (1993) studied this question.

synapsesocial.com/papers/6a88f6a2cd9902a7ca126955https://doi.org/10.1016/0014-5793(93)80350-4
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Possible regulatory functions of protein kinase C-α and -<i>ε</i> isoenzymes in rat renal mesangial cells. Stimulation of prostaglandin synthesis and feedback inhibition of angiotensin II-stimulated phosphoinositide hydrolysis1991 · 85 citations
  2. 2Overexpression of protein kinase C beta 1 enhances phospholipase D activity and diacylglycerol formation in phorbol ester-stimulated rat fibroblasts.1991 · 87 citations
  3. 3Evidence for a Role of Protein Kinase C ζ Subspecies in Maturation of <i>Xenopus laevis</i> Oocytes1992 · 158 citations
  4. 4Activation of phospholipase C and prostaglandin synthesis by [arginine]vasopressin in cultures1984 · 97 citations
  5. 5Endothelin stimulates phosphatidic acid formation in cultured rat mesangial cells: Role of a protein kinase C‐regulated phospholipase D1992 · 41 citations