October 22, 2004Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Angiotensin II–Induced Protein Kinase D Activation Is Regulated by Protein Kinase Cδ and Mediated via the Angiotensin II Type 1 Receptor in Vascular Smooth Muscle Cells

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Population

Vascular smooth muscle cells (SMCs)

Design

Preclinical

Authors

MTMingqi TanChina Medical University XXXuemin XuShandong University of Traditional Chinese Medicine MOMotoi OhbaMeharry Medical College

Discussion

Member takes

Implication

May guide PKCdelta-targeted studies in vascular remodeling; leaves open human translation.

Structured PICO

Population

Vascular smooth muscle cells (SMCs)

Intervention

Angiotensin II stimulation with or without PKC inhibitors, rottlerin, dominant-negative PKC isoforms, and selective Ang II receptor antagonists

Outcome

Mechanism of Angiotensin II-induced protein kinase D (PKD) activationsurrogate

Angiotensin II-induced PKD activation in vascular smooth muscle cells is mediated by the AT1 receptor and regulated by PKCdelta, providing insights into Ang II signaling mechanisms.

Cite This Study

Tan et al. (2004) studied this question.

synapsesocial.com/papers/6a88302b4ee1be090a58266c https://doi.org/10.1161/01.atv.0000148449.92035.3a

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Angiotensin II–Induced Protein Kinase D Activation Is Regulated by Protein Kinase Cδ and Mediated via the Angiotensin II Type 1 Receptor in Vascular Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II–Induced Protein Kinase D Activation Is Regulated by Protein Kinase Cδ and Mediated via the Angiotensin II Type 1 Receptor in Vascular Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider