Why the study?
Does Angiotensin II activate Akt/PKB and induce hypertrophy in glomerular mesangial cells?
Population
Glomerular mesangial cells (MCs)
Design
Preclinical
Authors
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Hypothesis-generating in animal mesangial cells; leaves open relevance to human glomerular disease.
Does Angiotensin II activate Akt/PKB and induce hypertrophy in glomerular mesangial cells?
Angiotensin II induces protein synthesis and hypertrophy in glomerular mesangial cells via an arachidonic acid/redox-dependent pathway that activates Akt/PKB independently of PI3-K.
Gorin et al. (2001) studied this question.
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