September 1, 2006Antioxidants and Redox Signaling

Arachidonic Acid–Dependent Activation of a p22 phox -Based NAD(P)H Oxidase Mediates Angiotensin II–Induced Mesangial Cell Protein Synthesis and Fibronectin Expression via Akt/PKB

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Population

Mesangial cells (MCs)

Comparison

Angiotensin II and Arachidonic Acid exposure… vs Control conditions

Design

Preclinical

Authors

KBKaren BlockVA Office of Research and Development JRJill M. RiconoCAB International DLDuck–Yoon Lee

Discussion

Member takes

Implication

Hypothesis-generating for p22phox targeting in mesangial cells; leaves open translation to renal disease models or patients.

Structured PICO

Population

Mesangial cells (MCs)

Intervention

Angiotensin II (Ang II) and Arachidonic Acid (AA) exposure, with various inhibitors (antisense p22phox, N-acetylcysteine)

Comparator

Control conditions (e.g., sense oligonucleotides, untreated cells)

Outcome

Akt/PKB activation, protein synthesis, and fibronectin expressionsurrogate

This study provides the first evidence in mesangial cells that arachidonic acid activates a p22phox-based NAD(P)H oxidase, mediating Angiotensin II-induced protein synthesis and fibronectin expression via Akt/PKB.

Cite This Study

Block et al. (2006) studied this question.

synapsesocial.com/papers/6a90872ce73a4c404fc94972 https://doi.org/10.1089/ars.2006.8.1497

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Arachidonic Acid–Dependent Activation of a p22 phox -Based NAD(P)H Oxidase Mediates Angiotensin II–Induced Mesangial Cell Protein Synthesis and Fibronectin Expression via Akt/PKB

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Arachidonic Acid–Dependent Activation of a p22 phox -Based NAD(P)H Oxidase Mediates Angiotensin II–Induced Mesangial Cell Protein Synthesis and Fibronectin Expression via Akt/PKB

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider