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September 15, 2006EndocrinologyOpen Access

Angiotensin II-Mediated Protein Kinase D Activation Stimulates Aldosterone and Cortisol Secretion in H295R Human Adrenocortical Cells

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Population

H295R human adrenocortical cells

Comparison

Angiotensin II treatment, PKC… vs Untreated cells or baseline conditions

Design

Preclinical

Authors

DRDamián G. RomeroBWBronwyn L. WelshEGElise P. Gómez-Sánchez

Discussion

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Overview

PKD may represent a therapeutic target in adrenal steroid excess; animal data leave clinical translation open.

Structured PICO

P
Population
H295R human adrenocortical cells
I
Intervention
Angiotensin II treatment, PKC activators/inhibitors, and constitutively active PKD mutant constructs
C
Comparator
Untreated cells or baseline conditions
O
Outcome
PKD phosphorylation and aldosterone/cortisol secretionsurrogate

Protein kinase D acts as an intracellular signaling mediator for Angiotensin II-induced aldosterone and cortisol secretion in human adrenal cells.

Cite This Study

Romero et al. (2006) studied this question.

synapsesocial.com/papers/6a841576356b31aeb3f2f28ahttps://doi.org/10.1210/en.2006-0794
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative proteomic analysis to identify the novel target gene of angiotensin II in adrenocortical H295R cells2020 · 2 citations
  2. 2Role of Protein Kinase C on the Steroidogenic Effect of Angiotensin II in the Rat Adrenal Glomerulosa Cell1990 · 46 citations
  3. 3Angiotensin II–Induced Protein Kinase D Activation Is Regulated by Protein Kinase Cδ and Mediated via the Angiotensin II Type 1 Receptor in Vascular Smooth Muscle Cells2004 · 27 citations
  4. 4cGMP-dependent Protein Kinase Type II Regulates Basal Level of Aldosterone Production by Zona Glomerulosa Cells without Increasing Expression of the Steroidogenic Acute Regulatory Protein Gene2003 · 60 citations
  5. 5Angiotensin II-Induced Protein Kinase D Activates the ATF/CREB Family of Transcription Factors and Promotes StAR mRNA Expression2014 · 21 citations