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September 16, 2004Physiological Genomics

Eleven genes were upregulated by ANG II, with maximum expression levels occurring 3-6 h after stimulation, preceding maximal aldosterone production.

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Why the study?

Does angiotensin II stimulation upregulate immediate-early genes in human adrenal H295R cells?

Population

human adrenal H295R cells

Comparison

Angiotensin II (ANG II) stimulation vs Other aldosterone secretagogues and baseline

Design

Preclinical

Follow-up

3-6 hours

Authors

DRDamián G. RomeroMPMaria W. PlonczynskiGVGastón Vergara-Hermosilla

Discussion

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Overview

Provides candidate effectors for ANG II-aldosterone synthesis; leaves open in vivo validation and clinical relevance.

Structured PICO

Does angiotensin II stimulation upregulate immediate-early genes in human adrenal H295R cells?

P
Population
human adrenal H295R cells
I
Intervention
Angiotensin II (ANG II) stimulation
C
Comparator
Other aldosterone secretagogues (K+, endothelin-1, ACTH) and baseline
O
Outcome
Immediate-early regulated gene expressionsurrogate

ANG II stimulates the expression of 11 immediate-early genes in human adrenal cells, providing candidate effectors for ANG II-mediated aldosterone synthesis.

Cite This Study

Romero et al. (2004) studied this question.

synapsesocial.com/papers/6a7a35cb77336a1bae02afaahttps://doi.org/10.1152/physiolgenomics.00097.2004
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Also Consider

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  1. 1Comparative proteomic analysis to identify the novel target gene of angiotensin II in adrenocortical H295R cells2020 · 2 citations
  2. 2Angiotensin II-Induced Expression of Brain-Derived Neurotrophic Factor in Human and Rat Adrenocortical Cells2010 · 29 citations
  3. 3Gene Expression and Roles of Angiotensin II Type 1 and Type 2 Receptors in Human Adrenals1998 · 32 citations
  4. 4Angiotensin II-Mediated Protein Kinase D Activation Stimulates Aldosterone and Cortisol Secretion in H295R Human Adrenocortical Cells2006 · 60 citations
  5. 5Hormonal regulation of angiotensin II type 1 receptor expression and AT<sub>1</sub>-R mRNA levels in human adrenocortical cells1995 · 37 citations