Why the study?
Although angiotensin II has various effects on cellular signaling in adrenal cells, its biological significance beyond aldosterone synthesis remains unclear.
Does Angiotensin II stimulation alter protein expression and glucose metabolism in human adrenocortical H295R cells?
Population
Human adrenal H295R cells
Comparison
Angiotensin II stimulation vs untreated cells
Design
In vitro comparative proteomic study using SILAC
Key result
Angiotensin II stimulation elevated the expression of phosphofructokinase type platelet (PFKP) by 1.52-fold at 24 hours and facilitated glucose uptake in human adrenal H295R cells.
Authors
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Should not change clinical practice; hypothesis-generating for Ang II effects on adrenocortical metabolism.
Does Angiotensin II stimulation alter protein expression and glucose metabolism in human adrenocortical H295R cells?
Angiotensin II upregulates phosphofructokinase type platelet (PFKP) via ERK1/2 signaling and increases glucose uptake in adrenocortical cells, indicating a novel role in glucose metabolism beyond steroidogenesis.
Ito et al. (2020) studied this question. Angiotensin II vs. Unstimulated cells was evaluated on Protein expression changes. Angiotensin II stimulation elevated the expression of phosphofructokinase type platelet (PFKP) by 1.52-fold at 24 hours and facilitated glucose uptake in human adrenal H295R cells.
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