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May 1, 1992AJP Endocrinology and Metabolism

Peripheral and central angiotensin II regulates expression of genes of the renin-angiotensin system

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Why the study?

Does angiotensin II regulate expression of genes of the renin-angiotensin system in peripheral and central tissues in rats?

Population

Male Sprague-Dawley rats (225-250 g)

Design

Preclinical

Follow-up

5 days

Authors

KKK. KoharaKagoshima UniversityKBK. Bridget BrosnihanAtrium Health Wake Forest BaptistCFCarlos M. FerrarioPreventive Cardiology

Discussion

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Implication

Route-specific ANG II effects on RAS genes in rats are hypothesis-generating; leaves open relevance to human cardiovascular regulation.

Structured PICO

Does angiotensin II regulate expression of genes of the renin-angiotensin system in peripheral and central tissues in rats?

P
Population
Male Sprague-Dawley rats (225-250 g)
I
Intervention
Angiotensin (ANG) II (0.1 or 6.0 nmol/h) infused by osmotic minipump for 5 days, either intravenously or intracerebroventricularly
O
Outcome
Expression of genes of the renin-angiotensin system (RAS) including angiotensinogen mRNA in liver, adrenal glands, and brain; renin mRNA in the kidney; and angiotensin-converting enzyme (ACE) mRNA in the lung and testissurrogate

Angiotensin II regulates the expression of renin-angiotensin system genes in a tissue- and route-specific manner, demonstrating complex feedback mechanisms in its formation.

Cite This Study

Kohara et al. (1992) studied this question.

synapsesocial.com/papers/6a79c75514b028facf0dfb1chttps://doi.org/10.1152/ajpendo.1992.262.5.e651
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The feedback regulation of angiotensinogen production by components of the renin-angiotensin system.1983 · 81 citations
  2. 2Cerebrospinal fluid angiotensin II immunoreactivity is not derived from the plasma.1985 · 21 citations
  3. 3Hybridization in Situ Studies of Angiotensinogen Gene Expression in Rat Adrenal and Lung*1989 · 48 citations
  4. 4Regulation of Angiotensinogen Gene1989 · 85 citations
  5. 5Glucocorticoid Regulation of Rat Diencephalon Angiotensinogen Production1990 · 34 citations