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January 1, 1990Endocrinology

Role of Protein Kinase C on the Steroidogenic Effect of Angiotensin II in the Rat Adrenal Glomerulosa Cell

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Population

Isolated rat adrenal glomerulosa cells

Comparison

Angiotensin II and/or 12-O-tetradecanoylphorbol-1… vs Basal conditions or inactive phorbol ester analog

Design

Preclinical

Follow-up

Up to 3 hours

Authors

SNShigeru NakanoPCPilar CarvalloSRStefano Rocco

Discussion

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Overview

No clinical implications for aldosterone disorders; leaves open distinct PKC mechanisms from phorbol esters in steroidogenesis.

Structured PICO

P
Population
Isolated rat adrenal glomerulosa cells
I
Intervention
Angiotensin II (AII) and/or 12-O-tetradecanoylphorbol-13-acetate (TPA)
C
Comparator
Basal conditions or inactive phorbol ester analog (4 alpha-hydroxyphorbol-12,13-dibutyrate)
O
Outcome
Protein kinase C (PKC) activity and aldosterone responsesurrogate

Angiotensin II activates PKC in rat adrenal glomerulosa cells, but AII and phorbol esters likely do not share the same mechanism of action in regulating steroidogenesis.

Cite This Study

Nakano et al. (1990) studied this question.

synapsesocial.com/papers/6a156b3f814bf8ec9a4e905bhttps://doi.org/10.1210/endo-126-1-125
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II-Mediated Protein Kinase D Activation Stimulates Aldosterone and Cortisol Secretion in H295R Human Adrenocortical Cells2006 · 60 citations
  2. 2Angiotensin II but not potassium induces subcellular redistribution of protein kinase C in bovine adrenal glomerulosa cells.1987 · 88 citations
  3. 3Effects of Angiotensin II, K<sup>+</sup>, Adrenocorticotropin, Serotonin, Adenosine 3′,5′-Monophosphate, Guanosine 3′,5′-Monophosphate, A23187, and EGTA on Aldosterone Synthesis and Phospholipid Metabolism in the Rat Adrenal Zona Glomerulosa*1983 · 59 citations
  4. 4A role for protein kinase C‐ϵ in angiotensin II stimulation of phospholipase D in rat renal mesangial cells1993 · 35 citations
  5. 5Long‐Term Activation of Protein Kinase C by Angiotensin II in Cultured Bovine Adrenal Medullary Cells1991 · 30 citations