Evidence for participation of calcineurin in potentiation of agonist-stimulated cyclic AMP formation by the calcium-mobilizing hormone, angiotensin II.
Population
Cultured bovine adrenal glomerulosa cells and COS-7 cells transfected with the rat AT1 receptor
Comparison
Angiotensin II and phorbol 12-myristate… vs Control cells or cells treated with ACTH alone
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Calcineurin inhibitors may blunt adrenal cAMP responses; hypothesis-generating for in vivo steroid regulation.
Structured PICO
P
Population
Cultured bovine adrenal glomerulosa cells and COS-7 cells transfected with the rat AT1 receptor
I
Intervention
Angiotensin II (AII) and phorbol 12-myristate 13-acetate (PMA) with or without inhibitors (cyclosporin A, FK506, rapamycin, staurosporine, pertussis toxin)
C
Comparator
Control cells or cells treated with ACTH alone
O
Outcome
cAMP levels/productionsurrogate
Angiotensin II enhances ACTH-stimulated cAMP production via a calcineurin-dependent mechanism, revealing cross-talk between Ca2+-mobilizing and cAMP-generating receptor pathways.
Cite This Study
Baukal et al. (1994) studied this question.