Key result
Angiotensin II induced dose-dependent expression of early growth response genes in bovine glomerulosa cells via the AT1 receptor, partially dependent on calcium mobilization and protein kinase C.
Population
Primary cultures of bovine adrenal glomerulosa cells
Comparison
Angiotensin II (AII) vs Baseline conditions, AT1 receptor antagonists…
Design
Preclinical
Authors
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May guide mechanistic studies of adrenal signaling; leaves open relevance to human hypertension or therapy.
Angiotensin II stimulates early growth response gene expression in bovine adrenal glomerulosa cells via AT1 receptors, utilizing both calcium and protein kinase C signaling pathways.
Clark et al. (1992) studied In vitro bovine adrenal glomerulosa cells. Angiotensin II vs. ACTH, ionomycin, thapsigargin, PMA was evaluated on Expression of early growth response genes (c-fos, c-jun, JunB, and Krox 24). Angiotensin II induced dose-dependent expression of early growth response genes in bovine glomerulosa cells via the AT1 receptor, partially dependent on calcium mobilization and protein kinase C.
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