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April 7, 2014EndocrinologyOpen Access

Angiotensin II-Induced Protein Kinase D Activates the ATF/CREB Family of Transcription Factors and Promotes StAR mRNA Expression

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Key result

Angiotensin II-induced protein kinase D activation promotes StAR mRNA expression by phosphorylating ATF-2 and CREB in primary bovine adrenal glomerulosa cells.

Population

Primary bovine adrenal glomerulosa cells

Comparison

Angiotensin II stimulation with overexpression… vs Vector control

Design

Preclinical

Authors

LOLawrence O. OlalaVCVivek ChoudharyMJMaribeth H. Johnson

Discussion

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Overview

Supports mechanistic studies of aldosterone regulation; leaves open relevance to human hypertension therapies.

Structured PICO

P
Population
Primary bovine adrenal glomerulosa cells
I
Intervention
Angiotensin II (AngII) stimulation with overexpression of constitutively active serine-to-glutamate PKD mutant or dominant-negative serine-to-alanine PKD mutant
C
Comparator
Vector control
O
Outcome
StAR mRNA expression, ATF-2 and CREB phosphorylation, and binding of phosphorylated CREB to the StAR promotersurrogate

Protein kinase D mediates Angiotensin II-induced acute aldosterone production by activating the ATF/CREB transcription factors and promoting StAR mRNA expression in adrenal glomerulosa cells.

Cite This Study

Olala et al. (2014) studied Aldosterone synthesis. Angiotensin II and PKD mutants vs. Vector control was evaluated on StAR mRNA expression and ATF-2/CREB phosphorylation. Angiotensin II-induced protein kinase D activation promotes StAR mRNA expression by phosphorylating ATF-2 and CREB in primary bovine adrenal glomerulosa cells.

synapsesocial.com/papers/6a15605079ff98d0de4e896chttps://doi.org/10.1210/en.2013-1485
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phosphorylation of Steroidogenic Acute Regulatory Protein (StAR) Modulates Its Steroidogenic Activity1997 · 388 citations
  2. 2Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia1997 · 452 citations
  3. 3Phorbol ester inhibits angiotensin-induced activation of phospholipase C in adrenal glomerulosa cells. Its implication in the sustained action of angiotensin1986 · 45 citations
  4. 4Unveiling the mechanism of action and regulation of the steroidogenic acute regulatory protein1998 · 84 citations