December 15, 2001Journal of Neurochemistry

Angiotensin II promotes the phosphorylation of cyclic AMP‐responsive element binding protein (CREB) at Ser133 through an ERK1/2‐dependent mechanism

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Population

Bovine adrenal chromaffin cells (BACC)

Design

Preclinical

Authors

MCMartı́n CammarotaUniversidade Federal do Rio Grande do Norte LBLia R. BevilaquaUniversidade Federal do Rio Grande do Norte PDPeter R. DunkleyHunter Medical Research Institute

Discussion

Member takes

Implication

No immediate clinical implications; leaves open whether AT1-ERK-CREB signaling modulates adrenal function in human cardiovascular disease.

Structured PICO

Population

Bovine adrenal chromaffin cells (BACC)

Intervention

Angiotensin II (AII) stimulation

Outcome

CREB phosphorylation at Ser133 (pCREB)surrogate

Angiotensin II upregulates CREB functionality in bovine adrenal chromaffin cells through a mechanism requiring Src-mediated activation of ERK1/2 and (p90)RSK.

Cite This Study

Cammarota et al. (2001) studied this question.

synapsesocial.com/papers/6a7f9df4a97e3300ffd76e84 https://doi.org/10.1046/j.1471-4159.2001.00666.x

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Implication

No immediate clinical implications; leaves open whether AT1-ERK-CREB signaling modulates adrenal function in human cardiovascular disease.

Angiotensin II promotes the phosphorylation of cyclic AMP‐responsive element binding protein (CREB) at Ser133 through an ERK1/2‐dependent mechanism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II promotes the phosphorylation of cyclic AMP‐responsive element binding protein (CREB) at Ser133 through an ERK1/2‐dependent mechanism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider