Population
Vascular smooth muscle cells (VSMC)
Comparison
ANG II stimulation with or without PKCzeta… vs Basal state or inactive controls (e.g., t-butanol)
Design
Preclinical
Authors
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May limit ANG II-induced VSMC hypertrophy in preclinical models; leaves open whether PKCzeta-PLD2 inhibition alters human vascular disease progression.
ANG II-induced PLD activation is regulated by PKCzeta, playing a crucial role in VSMC adhesion, spreading, and hypertrophy which are associated with atherosclerosis and malignant hypertension.
Parmentier et al. (2005) studied this question.
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