What does this research mean for the field?

Vascular collapse, rather than inexcitability or early metabolite accumulation, is the primary mechanism responsible for early ischemic contractile failure. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This investigation aims to elucidate the mechanisms underlying early ischemic contractile failure in heart tissue during ischemia.

January 1, 1991Circulation Research

Mechanism of early ischemic contractile failure. Inexcitability, metabolite accumulation, or vascular collapse?

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Population

Perfused ferret hearts at 27 degrees C

Comparison

Ordinary aortic flow occlusion vs Tissue-level ischemia induced by massive…

Design

Preclinical

Follow-up

5 minutes

Authors

YKYukihiro KoretsuneElectrophysiology MCMary C. CorrettiJohns Hopkins University HKHideo KusuokaCardiac Imaging

Discussion

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Implication

May implicate vascular collapse in early ischemic failure; hypothesis-generating in animal models, needs human validation.

Key Points

This investigation aims to elucidate the mechanisms underlying early ischemic contractile failure in heart tissue during ischemia.
Investigated perfused ferret hearts at 27 degrees C.
Measured isovolumic left ventricular developed pressure under total global ischemia.
Assessed vascular contributions using ordinary aortic flow occlusion and coronary microembolization.
Isovolumic left ventricular developed pressure decreased by over 50% within 30 seconds of total ischemia.
Monophasic action potential recordings showed no decrease in excitability.
Microembolized hearts exhibited slower functional depression despite similar metabolite accumulation.

Structured PICO

Population

Perfused ferret hearts at 27 degrees C

Intervention

Ordinary aortic flow occlusion (total global ischemia)

Comparator

Tissue-level ischemia induced by massive coronary microembolization at the level of the precapillary arterioles

Outcome

Time course of functional depression (isovolumic left ventricular developed pressure)surrogate

Vascular collapse plays a critical role in early ischemic contractile failure, preceding significant changes in excitability or metabolite accumulation.

Cite This Study

Koretsune et al. (1991) studied this question.

synapsesocial.com/papers/6a156b459b87f33fc69f8a1e https://doi.org/10.1161/01.res.68.1.255

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Mechanism of early ischemic contractile failure. Inexcitability, metabolite accumulation, or vascular collapse?

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Mechanism of early ischemic contractile failure. Inexcitability, metabolite accumulation, or vascular collapse?

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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