Why the study?
Does diet-induced hypercholesterolemia and subsequent regression alter the physicochemical and histological characteristics of arterial wall lesions in nonhuman primates?
Population
78 adult male cynomolgous macaques (Macaca fascicularis)
Comparison
Atherogenic diet for up to 30 months or 18… vs Basal monkey chow diet for 18, 24, and 30 months
Design
Preclinical, Assigned without conscious bias for controls; experimental groups…
Follow-up
up to 30 months
Authors
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Transient crystal formation may complicate early aggressive lipid lowering in primates; leaves open relevance to human plaque regression.
Does diet-induced hypercholesterolemia and subsequent regression alter the physicochemical and histological characteristics of arterial wall lesions in nonhuman primates?
In a nonhuman primate model, rapid reduction in serum cholesterol during early regression of atherosclerosis may transiently worsen lesions by precipitating cholesterol crystals, though prolonged regression improves the intima.
Small et al. (1984) studied this question.
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