September 1, 1980Circulation ResearchOpen Access

Reduction in pulse wave velocity and improvement of aortic distensibility accompanying regression of atherosclerosis in the rhesus monkey.

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Why the study?

Does a cholesterol-lowering regression diet improve aortic distensibility and reduce atherosclerosis in a rhesus monkey model?

Population

31 rhesus monkeys (Macaca mulatta) fed a high cholesterol diet for 38 months to induce atherosclerosis.

Comparison

24-month regression diets manipulated to… vs Continued high cholesterol progression diet…

Design

Preclinical

Follow-up

24 months (regression phase)

Authors

DFDavid J. FarrarHeart Failure / Cardiomyopathy HGH D Green WWWilliam D. WagnerWake Forest University

Discussion

Member takes

Overview

Supports reversibility of aortic stiffening via atherosclerosis regression in primates; leaves open human dietary translation.

Structured PICO

Does a cholesterol-lowering regression diet improve aortic distensibility and reduce atherosclerosis in a rhesus monkey model?

Population

31 rhesus monkeys (Macaca mulatta) fed a high cholesterol diet for 38 months to induce atherosclerosis.

Intervention

24-month regression diets manipulated to maintain plasma cholesterol concentrations at approximately 300 mg/dl (Group IIBi, n=10) or 200 mg/dl (Group IICi, n=12).

Comparator

Continued high cholesterol progression diet (Group IIA, n=9) resulting in an average plasma cholesterol concentration of 638 mg/dl.

Outcome

Subclavian-to-femoral artery pulse wave velocity at a diastolic blood pressure of 70 mm Hg.surrogate

In a rhesus monkey model, lowering plasma cholesterol through diet leads to regression of atherosclerosis and functional improvement in aortic elastic properties, as measured by reduced pulse wave velocity.

Cite This Study

Farrar et al. (1980) studied this question.

synapsesocial.com/papers/6a8512eae7eca461fe8481bb https://doi.org/10.1161/01.res.47.3.425

View Full Paper

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September 1, 1980Circulation ResearchOpen Access

Reduction in pulse wave velocity and improvement of aortic distensibility accompanying regression of atherosclerosis in the rhesus monkey.

View Full Paper

Ask AI

Bookmark

Why the study?

Does a cholesterol-lowering regression diet improve aortic distensibility and reduce atherosclerosis in a rhesus monkey model?

Population

31 rhesus monkeys (Macaca mulatta) fed a high cholesterol diet for 38 months to induce atherosclerosis.

Comparison

24-month regression diets manipulated to… vs Continued high cholesterol progression diet…

Design

Preclinical

Follow-up

24 months (regression phase)

Authors

DFDavid J. FarrarHeart Failure / Cardiomyopathy HGH D Green WWWilliam D. WagnerWake Forest University

Discussion

Member takes

Overview

Supports reversibility of aortic stiffening via atherosclerosis regression in primates; leaves open human dietary translation.

Structured PICO

Does a cholesterol-lowering regression diet improve aortic distensibility and reduce atherosclerosis in a rhesus monkey model?

Population

31 rhesus monkeys (Macaca mulatta) fed a high cholesterol diet for 38 months to induce atherosclerosis.

Intervention

24-month regression diets manipulated to maintain plasma cholesterol concentrations at approximately 300 mg/dl (Group IIBi, n=10) or 200 mg/dl (Group IICi, n=12).

Comparator

Continued high cholesterol progression diet (Group IIA, n=9) resulting in an average plasma cholesterol concentration of 638 mg/dl.

Outcome

Subclavian-to-femoral artery pulse wave velocity at a diastolic blood pressure of 70 mm Hg.surrogate

Cite This Study

Farrar et al. (1980) studied this question.

synapsesocial.com/papers/6a8512eae7eca461fe8481bb https://doi.org/10.1161/01.res.47.3.425

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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