What question did this study set out to answer?

This study investigates how the regression of atherosclerosis affects blood flow and vascular resistance in monkeys.

January 1, 1983Journal of Clinical InvestigationOpen Access

Hemodynamic sequelae of regression of experimental atherosclerosis.

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Why the study?

Does a regression diet improve vasodilator capacity and hemodynamics in cynomolgus monkeys with experimental atherosclerosis?

Population

29 adult male Malaysian cynomolgus monkeys (5.1 ± 0.9 kg)

Comparison

Regression diet for 18 months following 20… vs Atherogenic diet for 20 months and commercial…

Design

Preclinical

Follow-up

38 months

Authors

MAMark L. ArmstrongUniversity of Iowa DHDonald D. HeistadOregon National Primate Research Center MMMelvin L. MarcusCardiac Imaging

Discussion

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Implication

Regression may not restore vasodilator capacity uniformly across beds; leaves open functional benefits of lesion regression in primates.

Key Points

This study investigates how the regression of atherosclerosis affects blood flow and vascular resistance in monkeys.
Tested hemodynamic responses in normal, atherosclerotic, and regression diet monkeys (N=29).
Measured blood flow during maximal vasodilation using papaverine in the iliac artery and adenosine/hypercapnia in coronary and cerebral beds.
Assessed vascular resistance changes in relation to intimal fibrosis and luminal size.
Increased minimal vascular resistance in atherosclerotic monkeys (limb +108%, coronary +62%, cerebral +166%).
Regression monkeys showed inconsistent changes: limb resistance increased (+22%), coronary decreased (-19%), and cerebral decreased significantly (-44%, P<0.05).
Significant hemodynamic improvement observed only in cerebral vessels during maximal vasodilation.

Structured PICO

Does a regression diet improve vasodilator capacity and hemodynamics in cynomolgus monkeys with experimental atherosclerosis?

Population

29 adult male Malaysian cynomolgus monkeys (5.1 ± 0.9 kg)

Intervention

Regression diet (commercial chow) for 18 months following 20 months of an atherogenic diet (0.8% cholesterol, 41% fat)

Comparator

Atherogenic diet for 20 months (atherosclerotic group) and commercial chow only (normal group)

Outcome

Minimal vascular resistance in limb, coronary, and cerebral beds during maximal vasodilatationsurrogate

Increases in luminal size during regression of atherosclerotic lesions may not be associated with increases in vasodilator capacity, as intimal fibrosis may limit physiologically important hemodynamic improvement.

Cite This Study

Armstrong et al. (1983) studied this question.

synapsesocial.com/papers/6a2066b8d1cd0ea0c19cd803 https://doi.org/10.1172/jci110738

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Hemodynamic sequelae of regression of experimental atherosclerosis.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Hemodynamic sequelae of regression of experimental atherosclerosis.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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