Key result
Coronary heart disease diagnosed at least seven years before MRI scans was significantly associated with lower total gray matter volume (standardized β -0.150) and decreased cortical thickness.
Why the study?
Does coronary heart disease reduce cortical thickness and gray matter volume in elderly individuals at risk of dementia?
Population
69 elderly individuals at risk of dementia from the CAIDE study, mean age in midlife 49.9 years, 39.1% male…
Comparison
History of coronary heart disease diagnosed via… vs No history of coronary heart disease.
Design
Cohort
Follow-up
up to 30 years
Authors
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Chronic CHD may prompt cognitive monitoring in elderly at dementia risk; leaves open causal effects on brain structure.
Cohort (n=69)
No
Does coronary heart disease reduce cortical thickness and gray matter volume in elderly individuals at risk of dementia?
Effect estimate: standardized β -0.150
p-value: p=0.018
Long-term coronary heart disease is associated with detrimental effects on brain gray matter tissue and cortical thickness, which are further exacerbated by midlife hypertension and declining blood pressure.
Vuorinen et al. (2014) conducted a cohort in Coronary Heart Disease (n=69). Coronary Heart Disease vs. No Coronary Heart Disease was evaluated on Total gray matter volume (standardized β -0.150, p=0.018). Coronary heart disease diagnosed at least seven years before MRI scans was significantly associated with lower total gray matter volume (standardized β -0.150) and decreased cortical thickness.
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