Key result
Catheter ablation effectively maintains sinus rhythm versus AADs in AF and HFrEF, potentially reducing mortality.
Why the study?
AF and HFrEF reciprocally worsen clinical outcomes, making it important to review the evidence for catheter ablation to maintain sinus rhythm and improve mortality and hospitalization in this population.
Does catheter ablation improve mortality and hospitalization in patients with atrial fibrillation and heart failure with reduced ejection fraction?
Does catheter ablation improve mortality and hospitalization in patients with atrial fibrillation and heart failure with reduced ejection fraction?
This review highlights catheter ablation as an effective alternative to antiarrhythmic drugs for maintaining sinus rhythm and potentially reducing mortality and hospitalization in patients with AF and HFrEF.
May inform decisions in AF-HFrEF; leaves open need for RCTs to confirm mortality benefit.
Atrial fibrillation (AF) and heart failure with reduced ejection fraction (HFrEF) are two conditions that frequently impact reciprocally on each other. Patients with HFrEF have an increased risk of stroke, hospitalization and mortality after they develop AF and vice versa, AF causing deterioration of the ejection fraction is also associated to increased mortality. Catheter ablation has emerged as an effective alternative to antiarrhythmic drug treatment to maintain sinus rhythm and some randomized trials have shown a potential benefit in terms of mortality and hospitalization. This review discusses the available evidence regarding catheter ablation treatment in this specific patient group.
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Chiocchini et al. (2020) conducted a review in Atrial fibrillation and heart failure with reduced ejection fraction (HFrEF). Catheter ablation vs. Antiarrhythmic drug treatment was evaluated. Catheter ablation is an effective alternative to antiarrhythmic drugs for maintaining sinus rhythm in patients with AF and HFrEF, offering potential benefits in mortality and hospitalization.
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