Key result
Patients with lone AF had impaired baseline LV ejection fraction (61% vs 71%, P<0.001) and energetics (PCr/ATP 1.81 vs 2.05, P=0.004) compared to controls, which did not normalize after ablation.
Why the study?
Does catheter ablation improve left ventricular function and energetics in patients with lone atrial fibrillation?
Observational (n=78)
Does catheter ablation improve left ventricular function and energetics in patients with lone atrial fibrillation?
Absolute Event Rate: 61% vs 71%
p-value: p=<0.001
Lone AF is associated with impaired myocardial energetics and subtle LV dysfunction that do not normalize after successful catheter ablation, suggesting an underlying occult cardiomyopathy.
Authors
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Lone AF may reflect occult cardiomyopathy with persistent LV impairment post-ablation; leaves open whether ablation improves function or energetics.
Wijesurendra et al. (2016) conducted an observational in Lone atrial fibrillation (n=78). Catheter ablation vs. Matched control subjects in sinus rhythm was evaluated on Left ventricular ejection fraction (LVEF) (p=<0.001). Patients with lone AF had impaired baseline LV ejection fraction (61% vs 71%, P<0.001) and energetics (PCr/ATP 1.81 vs 2.05, P=0.004) compared to controls, which did not normalize after ablation.
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