Key result
In a 3D human atrial model, either or both I KACh and I K1 gradients were necessary to induce a left-to-right dominant frequency gradient during paroxysmal atrial fibrillation.
Why the study?
How specific ionic current gradients affect the left-to-right dominant frequency gradient during paroxysmal atrial fibrillation has not been studied.
How do specific ionic current gradients affect the left-to-right dominant frequency gradient during paroxysmal atrial fibrillation?
How do specific ionic current gradients affect the left-to-right dominant frequency gradient during paroxysmal atrial fibrillation?
In-silico modeling demonstrates that IKACh and IK1 gradients are necessary to induce a left-to-right dominant frequency gradient during paroxysmal atrial fibrillation, informing potential atrial-selective therapies.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for IKACh/IK1-targeted AF therapies; requires prospective validation beyond in-silico models.
Atrial fibrillation is the most prevalent cardiac arrhythmia. Paroxysmal atrial fibrillation (pAF) may occur in episodes lasting from minutes to days. Recent studies suggest that some pAF episodes present a left-to-right dominant frequency gradient caused by ionic current gradients. However, how each ionic current gradient affects the left-to-right dominant frequency gradient during pAF has not been studied. In this work, we use a 3D model of human atria to study how the ionic current gradients affect the dominant frequency gradient during pAF induced by continuous ectopic activity. The role of the specific gradients of acetylcholine-activated potassium current ( I KACh ) and inward-rectifier potassium current ( I K1 ) on determining the left-to-right dominant frequency gradient was assessed. The main outcome of this study is that either or both of the I KACh or I K1 gradients are necessary to induce a left-to-right dominant frequency gradient during pAF. However, both gradients are necessary to the left atrium maintaining, by itself, the pAF episode. These findings have potentially important implications for the development of atrial-selective therapeutic approaches.
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Palacio et al. (2019) studied Paroxysmal atrial fibrillation. Ionic current gradients (I KACh and I K1) was evaluated on Left-to-right dominant frequency gradient. In a 3D human atrial model, either or both I KACh and I K1 gradients were necessary to induce a left-to-right dominant frequency gradient during paroxysmal atrial fibrillation.
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