June 1, 2012Annals of Medicine
Blood pressure treatment target in patients with diabetes mellitus—current evidence
Key result
Current evidence suggests a personalized approach to blood pressure targets in diabetic patients, as aiming for systolic blood pressure <130 mmHg decreases stroke risk but may increase adverse events.
Why the study?
Does targeting specific blood pressure levels improve cardiovascular outcomes in patients with diabetes mellitus and hypertension?
Population
Patients with diabetes mellitus and hypertension
Comparison
Antihypertensive treatment targeting specific… vs Standard blood pressure targets or other blood…
Design
Review
Authors
Discussion
Loading...
Member takes
Implication
May warrant caution with SBP targets <130 mmHg in diabetes to limit adverse events; leaves open optimal thresholds for RCTs.
Structured PICO
Does targeting specific blood pressure levels improve cardiovascular outcomes in patients with diabetes mellitus and hypertension?
P
Population
Patients with diabetes mellitus (type 2 diabetes mellitus/impaired fasting glucose/impaired glucose tolerance) and hypertension
I
Intervention
Antihypertensive treatment targeting specific blood pressure levels (e.g., SBP 130-135 mmHg)
C
Comparator
Standard blood pressure targets or other blood pressure levels
O
Outcome
Cardiovascular disease mortality and stroke riskhard clinical
A personalized approach is recommended for antihypertensive treatment in diabetic patients, as aiming for SBP 130-135 mmHg is acceptable but very low BP may increase adverse events.
Limitations
- Very limited trial data on low attained BP level
- Currently available very limited trial data on low attained BP level
Cite This Study
Barengo et al. (2012) conducted a review in Hypertension in diabetes mellitus. Blood pressure treatment targets was evaluated. Current evidence suggests a personalized approach to blood pressure targets in diabetic patients, as aiming for systolic blood pressure <130 mmHg decreases stroke risk but may increase adverse events.