Key result
Pharmacological RyR2 targeting emerges as a potential therapeutic strategy for managing HF and arrhythmias.
Why the study?
Cardiac diseases remain leading causes of death worldwide, motivating efforts to unravel molecular pathomechanisms and identify new therapeutic targets such as RyR2 in cardiac ryanopathies.
This review summarizes the pathological mechanisms of ryanopathies and discusses pharmacological approaches targeting the cardiac ryanodine receptor (RyR2).
RyR2-targeted agents merit preclinical study in ryanopathies; leaves open clinical efficacy and safety in heart failure or arrhythmias.
Cardiac diseases are the leading causes of death, with a growing number of cases worldwide, posing a challenge for both healthcare and research. Therefore, the most relevant aim of cardiac research is to unravel the molecular pathomechanisms and identify new therapeutic targets. Cardiac ryanodine receptor (RyR2), the Ca2+ release channel of the sarcoplasmic reticulum, is believed to be a good therapeutic target in a group of certain heart diseases, collectively called cardiac ryanopathies. Ryanopathies are associated with the impaired function of the RyR, leading to heart diseases such as congestive heart failure (CHF), catecholaminergic polymorphic ventricular tachycardia (CPVT), arrhythmogenic right ventricular dysplasia type 2 (ARVD2), and calcium release deficiency syndrome (CRDS). The aim of the current review is to provide a short insight into the pathological mechanisms of ryanopathies and discuss the pharmacological approaches targeting RyR2.
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Szentandrássy et al. (2022) conducted a review in Ryanodine Receptor-Associated Heart Diseases (Ryanopathies). Pharmacological approaches targeting RyR2 was evaluated. Pharmacological approaches targeting the cardiac ryanodine receptor (RyR2) are discussed as potential therapeutic strategies for managing ryanopathies, including heart failure and arrhythmias.
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