Key result
Both hypoinsulinemia and hyperinsulinemia demonstrated a significant independent U-shaped association with carotid atherosclerosis progression over a 5-year follow-up.
Why the study?
Is there an association between serum insulin levels and the progression of carotid atherosclerosis in the general population?
Population
888 men and women aged 40 to 79 years from the general population.
Comparison
Low and high serum insulin levels. vs Intermediate serum insulin levels.
Design
Cohort
Follow-up
5 years
Authors
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Should not yet guide insulin monitoring in practice; extends prior CHD associations to carotid progression but leaves causality open.
Cohort (n=888)
Is there an association between serum insulin levels and the progression of carotid atherosclerosis in the general population?
Both hypoinsulinemia and hyperinsulinemia are independent risk indicators for the progression of carotid atherosclerosis in the general population.
Bonora et al. (1997) conducted a cohort in Carotid atherosclerosis (n=888). Serum insulin (fasting and 2 hours post-glucose load) vs. Quintiles of baseline serum insulin was evaluated on Progression of carotid atherosclerosis (increase in score >27% or occurrence of new plaques). Both hypoinsulinemia and hyperinsulinemia demonstrated a significant independent U-shaped association with carotid atherosclerosis progression over a 5-year follow-up.