Key result
ECG-gated MDCT in 74 healthy subjects demonstrated that sex and body surface area significantly influence left atrial volume, function, and diameter, allowing for normalized reference values.
Why the study?
What are the normal reference values for left atrial volume, function, and diameter derived from ECG-gated MDCT?
Observational (n=74)
What are the normal reference values for left atrial volume, function, and diameter derived from ECG-gated MDCT?
This study establishes normal reference values for left atrial volume, function, and diameter using ECG-gated MDCT, highlighting the importance of indexing these parameters to sex and body surface area.
May inform ECG-gated MDCT LA reference values indexed to sex and BSA; leaves open prospective validation before clinical adoption.
OBJECTIVE: The purpose of this study was to retrospectively determine CT-based normal reference values of left atrial volume, function, and diameter normalized by age, sex, and body surface area. MATERIALS AND METHODS: The study group consisted of 74 subjects with normal findings at ECG-gated coronary CT angiography performed with retrospective gating. Analysis of left atrial volume (end-diastolic, end-systolic, and stroke volume) and function (ejection fraction) was performed with the Simpson method. Left atrial diameter was measured in the anteroposterior dimension. General linear model analysis was performed to model the data and assess statistical significance by age group after adjustment for sex and body surface area. RESULTS: The reference range for left atrial volume, function, and diameter was normalized (indexed) to age, sex, and body surface area in healthy subjects. A statistically significant difference was noted between left atrial volume and age without adjustment for sex and body surface area, but no statistically significant difference was found after adjustment for these variables. Sex and body surface area had a significant influence on left atrial volume, function, and diameter. CONCLUSION: Left atrial volume, function, and diameter normalized to age, sex, and body surface area can be reported from CTA datasets and may provide information important for patient care.
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Stojanovska et al. (2011) conducted an observational in Healthy subjects with normal findings (n=74). ECG-gated MDCT was evaluated on Left atrial volume, function, and diameter normalized by age, sex, and body surface area. ECG-gated MDCT in 74 healthy subjects demonstrated that sex and body surface area significantly influence left atrial volume, function, and diameter, allowing for normalized reference values.
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