Key result
Maximal exercise testing in young patients with nonobstructive HCM showed that all 3 patients with cardiac events and 3 of 10 without events had a stroke volume response (%SVend) of less than 100%.
Why the study?
Does maximal symptom-limited bicycle exercise testing reveal abnormal stroke volume and blood pressure responses in young patients with nonobstructive hypertrophic cardiomyopathy?
Population
13 young patients with nonobstructive hypertrophic cardiomyopathy in NYHA class I, and 21 healthy young…
Comparison
Maximal symptom-limited bicycle exercise testing… vs Healthy young control subjects
Design
Cohort
Follow-up
mean 7.4 years (range, 2-18 years)
Authors
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May flag higher event risk in young nonobstructive HCM; leaves open whether it aids risk stratification or requires prospective validation.
Observational (n=13)
Does maximal symptom-limited bicycle exercise testing reveal abnormal stroke volume and blood pressure responses in young patients with nonobstructive hypertrophic cardiomyopathy?
Young patients with nonobstructive HCM and a history of cardiac events exhibit an abnormal, blunted stroke volume response to exercise, suggesting a mechanism for exercise-related sudden cardiac death.
Yasui et al. (2001) conducted an observational in Nonobstructive hypertrophic cardiomyopathy (HCM) (n=13). Maximal symptom-limited bicycle exercise testing vs. Control group was evaluated on Ratio of stroke volume at termination of exercise to rest (%SVend). Maximal exercise testing in young patients with nonobstructive HCM showed that all 3 patients with cardiac events and 3 of 10 without events had a stroke volume response (%SVend) of less than 100%.
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