Key result
Hypertension linked to ~21% greater carotid intima media thickness versus controls.
Why the study?
Given the rising incidence of cardiovascular disease in the developing world, it is important to identify which cardio-metabolic risk factors contribute most to the development of atherosclerosis in hypertensive patients.
Is hypertension associated with increased carotid intima media thickness compared to non-hypertensive controls?
Cross-Sectional (n=133)
No
Is hypertension associated with increased carotid intima media thickness compared to non-hypertensive controls?
Absolute Event Rate: 0.969% vs 0.8%
p-value: p=<0.001
Hypertension is significantly associated with increased carotid intima-media thickness, highlighting its major role in the development of subclinical atherosclerosis.
Supports hypertension's role in subclinical atherosclerosis; leaves open causal and therapeutic implications for prospective studies.
Objectives: In the presence of the rising incidence of cardiovascular disease in the developing world, it is imperative to focus on prevention. Many cardio-metabolic risk factors are responsible for development of atherosclerosis in hypertensive patients. It is important to know which factors contribute the most to this condition. Study Design: Cross Sectional study. Setting: Departments of Medicine and Radiology at Creek General Hospital, United Medical and Dental College, Karachi. Period: June 2015 to June 2016. Material & Methods: Planned and the subjects were selected by consecutive sampling. Physical examination data and laboratory reports were obtained. All the subjects underwent Carotid Doppler studies. The data as analyzed on SPSS ver.20.0. Relationship of the variables to CIMT was ascertained by Pearson’s Correlation in both hypertensive and non-hypertensive subjects. P-value of <0.05 was considered significant. Results: All the variables like age, BMI, glycemic indices and the different fractions of the lipid profile were significantly higher in hypertensive patients. CIMT was significantly higher in hypertensive patients. The studied cardiometabolic variables were related to CIMT in both groups of patients but these variables were related more strongly in subjects without hypertension confirming the assumption that hypertension plays a major role in atherosclerosis. Conclusion: Hypertension is one of the most potent modifiable risk factors contributing to atherosclerosis.
No takes yet. Share an insight, caveat, or question.
Bashir et al. (2020) conducted a cross-sectional in Hypertension (n=133). Hypertension vs. Non-hypertensive controls was evaluated on Carotid intima media thickness (CIMT) in mm (p=<0.001). Hypertension was associated with significantly higher carotid intima media thickness compared to non-hypertensive controls (0.969 mm vs 0.80 mm, p<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: