Key result
An elevated TyG Index was strongly associated with subclinical atherosclerosis (CIMT ≥ 0.8 mm) in hypertensive patients, with an odds ratio of 7.938.
Why the study?
The study sought to identify independent determinants of selected emerging cardiometabolic risk factors of increased carotid intima-media thickness in uncontrolled hypertensive patients in a hospital setting in Kinshasa.
Cross-Sectional (n=280)
Yes
Odds Ratio: 7.938 (95% CI 3.445–18.288)
p-value: p=<0.0001
In hypertensive patients in DR Congo, urinary albumin/creatinine ratio, TyG index, BMI, and LVMI are independent predictors of subclinical atherosclerosis as measured by elevated CIMT.
May support risk stratification in sub-Saharan hypertensives; hypothesis-generating and requires prospective validation before practice change.
Objective: To identify independent determinants of selected emerging cardiometabolic risk factors of increased carotid intima – media thickness (CIMT) in uncontrolled hypertensive patients in a hospital setting in Kinshasa. Material and method: A cross-sectional study was performed between September 2018 and January 2021 in hypertensive patients admitted to Cliniques Universitaires de Kinshasa (CUK), Centre Hospitalier Mère et Enfant Monkole (CHME) and Hôpital Biamba Marie Mutombo (HBMM) to measure CIMT on ultra sonography. Some cardiometabolic and atherogenic markers were evaluated by Receiver Operating Characteristic (ROC) and logistical regression. Results: 280 hypertensive patients were examined with 72.9% uncontrolled hypertension. The CMIT threshold >0.8 mm associated with uncontrolled hypertension was significantly and independently predictive of subclinical atherosclerosis. Conclusion: The present study identified independent determinants of increased CIMT in globally uncontrolled hypertensive patients in a hospital setting in Kinshasa, DR Congo. Thus, the optimal and specific thresholds for subclinical atherosclerosis were: urinary albumin/creatinine ratio, TyG Index, BMI and LVMI in the direction of health promotion and atherosclerosis prevalence in the management of hypertensive patients in the hospital setting of Kinshasa, DR Congo.
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Tongo et al. (2022) conducted a cross-sectional in Hypertension (n=280). Elevated TyG Index vs. Lower TyG Index was evaluated on Increased carotid intima-media thickness (CIMT ≥ 0.8 mm) (OR 7.938, 95% CI 3.445-18.288, p=<0.0001). An elevated TyG Index was strongly associated with subclinical atherosclerosis (CIMT ≥ 0.8 mm) in hypertensive patients, with an odds ratio of 7.938.
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