Key result
A 6-day moderate-exercise intervention produced a significantly greater reduction in triglycerides in men with the apo C-III S2S2 genotype compared to those with the S1S1 genotype (P=0.047).
Why the study?
Does a 6-day moderate-exercise intervention reduce fasting triglycerides differently depending on apolipoprotein C-III SstI genotype in Korean men?
Cohort (n=100)
Does a 6-day moderate-exercise intervention reduce fasting triglycerides differently depending on apolipoprotein C-III SstI genotype in Korean men?
p-value: p=0.047
Apo C-III genotype may modulate short-term exercise effects on triglycerides; hypothesis-generating and requires larger validation before clinical consideration.
PURPOSE: To investigate whether the efficacy of exercise as an antitriglyceridemic treatment was dependent on the apolipoprotein (apo) C-III SstI gene polymorphism. METHODS: A subgroup of 100 Korean men, who were prescreened by genotypes (S1S1 = 40, S1S2 = 40, S2S2 = 20), participated in a 6-d moderate-exercise intervention using either a motor-driven treadmill or a cycle ergometer. Height and weight for body mass index and waist circumference were measured. Fasting total cholesterol, triglycerides (TG), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, glucose, and insulin were measured. Univariate analysis of variance and ANCOVA followed by Bonferroni post hoc tests were used to compare the preintervention values and the pre- to postexercise change (delta) scores in the measured variables across the genotypes, respectively. Multivariate linear regressions were carried out with age, smoking, waist circumference, body mass index, and genotype as independent variables and lipids, glucose, and insulin as dependent variables. RESULTS: Subjects with the S2S2 genotype had a significantly higher preintervention TG concentration than subjects with the S1S1 genotype (P = 0.022). Waist circumference and genotype were the only significant predictors for the preintervention TG (P < 0.001). With respect to the delta scores, the subjects with the S2S2 genotype had a greater reduction in TG than the subjects with the S1S1 genotype, adjusted for the preintervention difference (P = 0.047). CONCLUSION: This study suggests that the apo C-III SstI gene polymorphism might be useful for determining who is most susceptible to intervention by exercise in lowering fasting TG concentration.
No takes yet. Share an insight, caveat, or question.
Woo et al. (2004) reported a cohort. Moderate-exercise intervention vs. S1S1 genotype was evaluated on Pre- to postexercise change in triglycerides (p=0.047). A 6-day moderate-exercise intervention produced a significantly greater reduction in triglycerides in men with the apo C-III S2S2 genotype compared to those with the S1S1 genotype (P=0.047).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: