Why the study?
Do immobilized catecholamines and cocaine affect the contractility of cat papillary muscles?
Population
Isometrically contracting papillary muscles from cats
Comparison
Immobilized catecholamines with or without 1 muM… vs Isoproterenol in solution
Design
Preclinical
Follow-up
more than 5 hr
Authors
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No change to clinical inotrope use; leaves open membrane receptor localization as a research target in myocardium.
Do immobilized catecholamines and cocaine affect the contractility of cat papillary muscles?
The study demonstrates that immobilized catecholamines exert a positive inotropic effect on cat papillary muscles, suggesting their primary site of action is on receptors located on the extended surface of myocardial cells.
Venter et al. (1973) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: