Population
Kitten papillary muscles
Design
Preclinical
Authors
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Caffeine effects on ventricular APD and contractility warrant caution in extrapolation; leaves open human translation and mechanistic confirmation.
Caffeine alters the action potential duration and increases isometric contraction tension in mammalian ventricular muscle, potentially via increased membrane calcium current and intracellular calcium release.
CLARK et al. (1973) studied this question.
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