Key result
PKA-catalysed phosphorylation of human cardiac troponin-I occurs sequentially (Ser-24 preceding Ser-23), inducing a conformational transition that may regulate calcium sensitivity.
Population
Peptide corresponding to the N-terminal region of human cardiac troponin-I (residues 17-30)
Design
Preclinical
Authors
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No immediate implications for patient care; leaves open the functional impact of sequential troponin-I phosphorylation in vivo.
The second phosphorylation at Ser-23 of cardiac troponin-I may be key in how adrenaline regulates the calcium sensitivity of the myofibrillar actomyosin Mg-ATPase.
Quirk et al. (1995) studied Cardiac troponin-I phosphorylation. PKA-catalysed phosphorylation was evaluated on Phosphorylation sequence and conformational transition. PKA-catalysed phosphorylation of human cardiac troponin-I occurs sequentially (Ser-24 preceding Ser-23), inducing a conformational transition that may regulate calcium sensitivity.
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