Key result
Sequential phosphorylation and dephosphorylation of cardiac troponin I by PKA and PP2A generates four different species depending on the active kinase/phosphatase concentration ratio.
This study identifies a new principle of pattern generation in signal cascades involving multiple phosphorylation sites on cardiac troponin I.
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Suggests ratio-dependent troponin I phosphoforms in animals; leaves open translation to human cardiac signaling and disease.
Jaquet et al. (1995) studied Cardiac troponin I phosphorylation. cAMP-dependent protein kinase (PKA) and protein phosphatase 2A (PP2A) was evaluated on Concentration changes of different troponin I species. Sequential phosphorylation and dephosphorylation of cardiac troponin I by PKA and PP2A generates four different species depending on the active kinase/phosphatase concentration ratio.
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