Key result
In the presence of augmented late sodium current, amiodarone (30-300 nM) induced torsade de pointes in 16 of 17 isolated rabbit hearts, while higher concentrations (1-10 µM) suppressed it.
Why the study?
Does acute exposure to amiodarone induce torsade de pointes in an animal model with augmented late sodium current?
Population
Female rabbit isolated hearts and human embryonic kidney cells expressing SCN5A Na+ and HERG K+ channels
Comparison
Acute exposure to amiodarone in the presence of… vs Acute amiodarone alone (without ATX-II)
Design
Preclinical
Authors
Loading...
Amiodarone may promote torsade de pointes at low concentrations with augmented late sodium current; leaves open net clinical arrhythmic risk.
Does acute exposure to amiodarone induce torsade de pointes in an animal model with augmented late sodium current?
p-value: p=<0.01
This preclinical model demonstrates that amiodarone has a concentration-dependent biphasic effect, inducing torsade de pointes when late sodium current is augmented, and suppressing it at higher concentrations.
Wu et al. (2007) studied Torsade de pointes (TdP) (n=17). Amiodarone vs. Acute amiodarone alone / Baseline was evaluated on Induction of Torsade de pointes (TdP) and changes in MAPD90 (p=<0.01). In the presence of augmented late sodium current, amiodarone (30-300 nM) induced torsade de pointes in 16 of 17 isolated rabbit hearts, while higher concentrations (1-10 µM) suppressed it.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: