Key result
Aldosterone's effect on systolic blood pressure intensified as age increased, especially in blacks (P<0.01), suggesting an increased aldosterone sensitivity with age compared to whites.
Why the study?
Does aldosterone sensitivity increase with age differently in normotensive black versus white individuals?
Population
605 normotensive individuals studied as children and followed into young adulthood over an age range of 7 to…
Design
Cohort
Follow-up
from childhood to young adulthood (age range 7 to 39 years)
Authors
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May support race-specific aldosterone targeting in older blacks; hypothesis-generating and needs prospective confirmation.
Cohort (n=605)
Does aldosterone sensitivity increase with age differently in normotensive black versus white individuals?
p-value: p=<0.01
Aldosterone sensitivity increases with age significantly more in black individuals than white individuals, providing a pathophysiological rationale for targeting aldosterone in the treatment of hypertension in black patients.
Tu et al. (2018) conducted a cohort in Normotension (n=605). Plasma aldosterone concentration vs. Whites was evaluated on Influence of aldosterone on systolic blood pressure (aldosterone sensitivity) (p=<0.01). Aldosterone's effect on systolic blood pressure intensified as age increased, especially in blacks (P<0.01), suggesting an increased aldosterone sensitivity with age compared to whites.
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