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November 1, 1991The Journal of Clinical Endocrinology & Metabolism

Diagnosis under Random Conditions of All Disorders of the Renin-Angiotensin-Aldosterone Axis, Including Primary Hyperaldosteronism

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Why the study?

Can a single random PA/PRA ratio accurately diagnose disorders of the renin-angiotensin-aldosterone axis?

Population

126 patients, including those with primary hyperaldosteronism, chronic renal failure, secondary…

Design

Cross-sectional

Authors

TMT. J. McKennaNova Southeastern UniversitySSS. J. SequeiraUniversity College DublinAHAndrew HeffernanUniversity of Ottawa

Discussion

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Implication

May streamline PA axis disorder screening from one sample; leaves open prospective validation before practice change.

Structured PICO

Can a single random PA/PRA ratio accurately diagnose disorders of the renin-angiotensin-aldosterone axis?

P
Population
126 patients, including those with primary hyperaldosteronism (n=10), chronic renal failure (n=17), secondary hyperaldosteronism (n=14), primary adrenal insufficiency (n=19), hyporeninemic hypoaldosteronism (n=7), and nonadrenal disorders (n=59).
I
Intervention
Measurement of plasma aldosterone (PA) to plasma renin activity (PRA) ratio from a single blood sample under random conditions
O
Outcome
Diagnosis of disorders of the renin-angiotensin-aldosterone axissurrogate

A single random blood sample measuring the PA/PRA ratio can accurately diagnose primary hyperaldosteronism and other adrenal disorders, simplifying the diagnostic workup.

Cite This Study

McKenna et al. (1991) studied this question.

synapsesocial.com/papers/6a159faf79ff98d0de4ee7fbhttps://doi.org/10.1210/jcem-73-5-952
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IS ALDOSTERONE/RENIN RATIO USEFUL TO SCREEN A HYPERTENSIVE POPULATION FOR PRIMARY ALDOSTERONISM?1985 · 75 citations
  2. 2Application of a Radioimmunoassay for Angiotensin I to the Physiologic Measurements of Plasma Renin Activity in Normal Human Subjects<sup>1</sup>1969 · 2,239 citations
  3. 3Effect of Sodium Concentration on Aldosterone Secretion by Isolated Perfused Canine Adrenal Glands*1984 · 50 citations
  4. 4Evaluation of an Aldosterone Radioimmunoassay: The Renin—Angiotensin—Aldosterone Axis as a Function of Sex and Age1986 · 19 citations
  5. 5The Renin-Angiotensin-Aldosterone System in Normotensive and Hypertensive Patients with Acromegaly1972 · 56 citations