Why the study?
What is the diagnostic accuracy of different screening parameters (SA, PRA, SA/PRA ratio) for primary aldosteronism in hypertensive patients?
Population
345 hypertensive patients evaluated at a tertiary-care centre
Design
Cohort
Authors
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May reduce false positives when screening hypertensive patients for primary aldosteronism; leaves open prospective validation before changing practice.
What is the diagnostic accuracy of different screening parameters (SA, PRA, SA/PRA ratio) for primary aldosteronism in hypertensive patients?
Combining the SA/PRA ratio with an absolute serum aldosterone threshold or using SA(2)/PRA improves diagnostic accuracy for primary aldosteronism and reduces false positives compared to the SA/PRA ratio alone.
Seiler et al. (2004) studied this question.
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