Key result
In 3 patients with primary hyperaldosteronism and severe hypertension, hypertensive kidney damage caused PRA to escape suppression, though they responded to 200 mg/day spironolactone.
Case Report (n=3)
In primary hyperaldosteronism with severe hypertension, hypertensive kidney damage can cause plasma renin activity to escape suppression, though the aldosterone/renin ratio remains elevated and useful for screening.
No takes yet. Share an insight, caveat, or question.
Suggests kidney damage may cause PRA escape in primary hyperaldosteronism; leaves open spironolactone dosing implications.
Oelkers et al. (2000) conducted a case report in Primary hyperaldosteronism (n=3). Spironolactone was evaluated. In 3 patients with primary hyperaldosteronism and severe hypertension, hypertensive kidney damage caused PRA to escape suppression, though they responded to 200 mg/day spironolactone.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: