Key result
Captopril administration significantly decreased arterial pressures and increased heart rate, with greater effects and altered baroreflex parameters in 1-week-old compared to 6-week-old lambs.
Why the study?
Does captopril administration affect arterial baroreflex control of heart rate differently in 1-week-old versus 6-week-old conscious lambs?
Population
16 conscious, chronically instrumented lambs aged approximately 1 week or approximately 6 weeks
Comparison
Captopril administration vs Baseline (before captopril administration)
Design
Preclinical
Authors
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Indicates stronger Ang II role in neonatal baroreflex; hypothesis-generating for age-specific effects in human infants.
Does captopril administration affect arterial baroreflex control of heart rate differently in 1-week-old versus 6-week-old conscious lambs?
Angiotensin II plays a more predominant role in modulating cardiovascular homeostasis and baroreflex control of heart rate in newborn lambs compared to older lambs.
Monument et al. (2003) studied Conscious, chronically instrumented lambs (n=16). Captopril vs. Baseline (before administration) was evaluated on Arterial baroreflex control of heart rate and arterial pressures. Captopril administration significantly decreased arterial pressures and increased heart rate, with greater effects and altered baroreflex parameters in 1-week-old compared to 6-week-old lambs.
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