Why the study?
Does angiotensin II affect mean arterial pressure and renal blood flow via AT1 or AT2 receptors in conscious lambs?
Does angiotensin II affect mean arterial pressure and renal blood flow via AT1 or AT2 receptors in conscious lambs?
In conscious lambs during the first 6 weeks of life, the pressor and renal vasoconstrictor effects of angiotensin II are mediated exclusively by AT1 receptors.
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Confirms exclusive AT1 mediation of ANG II effects in neonatal lambs; leaves open translation to human infants or practice.
Chappellaz et al. (2005) studied this question.
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