May 1, 2014Physiological ReportsOpen Access

Angiotensin receptors modulate the renal hemodynamic effects of nitric oxide in conscious newborn lambs

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Population

Conscious, chronically instrumented lambs aged ~1 week (8 ± 1 days, N = 8) and ~6 weeks (41 ± 2 days, N = 8)

Design

Preclinical

Authors

AVAngela VinturacheUniversity of Lethbridge FSFrancine G. SmithUniversity of Calgary

Discussion

Member takes

Implication

AT2R predominance in neonatal lamb renal NO response is hypothesis-generating; leaves open translation to human neonates and age-specific therapies.

Structured PICO

Population

Conscious, chronically instrumented lambs aged ~1 week (8 ± 1 days, N = 8) and ~6 weeks (41 ± 2 days, N = 8)

Intervention

l-NAME administration after pretreatment with AT1R antagonist (ZD 7155), AT2R antagonist (PD 123319), or both

Outcome

Changes in systolic, diastolic, and mean arterial pressure (SAP, DAP, MAP), venous pressure (MVP), renal blood flow (RBF), and renal vascular resistance (RVR)surrogate

In newborn lambs, AT2 receptors play a predominant role in modulating the renal hemodynamic effects of nitric oxide, highlighting an age-dependent interaction between the renin-angiotensin and NO pathways.

Cite This Study

Vinturache et al. (2014) studied this question.

synapsesocial.com/papers/6a7eb1356cdd7a4db302681d https://doi.org/10.14814/phy2.12027

View Full Paper

Ask AI

Bookmark

Implication

AT2R predominance in neonatal lamb renal NO response is hypothesis-generating; leaves open translation to human neonates and age-specific therapies.

Angiotensin receptors modulate the renal hemodynamic effects of nitric oxide in conscious newborn lambs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin receptors modulate the renal hemodynamic effects of nitric oxide in conscious newborn lambs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider