Key result
Jiashen tablets improve cardiac function and limit fibrosis in HF rats by restoring 29 metabolites.
Why the study?
Jiashen tablets are reported to effectively treat heart failure, but the underlying mechanisms remain obscure.
Does Jiashen tablets improve cardiac function and metabolic profiles in a rat model of heart failure?
Does Jiashen tablets improve cardiac function and metabolic profiles in a rat model of heart failure?
Jiashen tablets ameliorate heart failure in a rat model by improving cardiac function, reducing myocardial fibrosis, and regulating amino acid and lipid metabolism.
Answers are grounded in this paper and cite their sources.
Preclinical data suggest metabolic benefits of Jiashen tablets in HF rats; leaves open human applicability.
Background: Heart failure is a chronic progressive condition that significantly affects the quality of life of patients with high hospitalization and mortality rates. Jiashen tablets (JST), a Chinese herbal formula, have been reported to be an effective treatment against heart failure, however the underlying mechanisms remain obscure. This study was designed to determine the effect of JST on the treatment of heart failure and delineate the underlying mechanisms by an untargeted metabolomics approach. Materials and methods: The chronic heart failure model was established by the permanent ligation of the left anterior descending coronary artery in rats. The cardiac functions of rats, including left ventricular ejection fraction (LVEF) and fractional shortening (LVFS), left ventricular internal diameter end diastole (LVIDd) and end systole (LVIDs), and interventricular septum thickness in diastole (IVSd) and in systole (IVSs), were measured by echocardiography. Biochemical analysis and histopathological examination were also performed to evaluate therapeutic effects of JST for treating heart failure. UHPLC-QTOF-MS/MS coupled with multivariate statistical analyses were applied for plasma metabolic profiling to identify biomarkers and potential mechanisms of JST in the treatment of heart failure. Results: Jiashen tablets could improve the cardiac function of heart failure rats and thus ameliorate heart failure via enhancing rat LVEF and LVFS and decreasing LVIDd, LVIDs, IVSd, and IVSs. Results of biochemical analysis and histopathological examination revealed that JST could reduce the serum lactate dehydrogenase (LDH) activity and the level of NT-pro BNP, markers of heart failure and myocardial damage, and inhibit myocardial fibrosis. Furthermore, in metabolomics analysis, a total of 210 metabolites with significant differences were identified between heart failure rats and normal rats, among which 29 metabolites were significantly restored after JST treatment. These metabolites were primarily involved in tryptophan metabolism, branched-chain amino acid metabolism, fatty acids β-oxidation, and glycerophospholipid metabolism. Conclusion: The present study illustrated the therapeutic effect of JST for the treatment of heart failure and delineated the underlying mechanisms mainly relating to the regulation of amino acid metabolism and lipid metabolism in heart failure rats.
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Miao et al. (2022) studied Heart failure (n=52). Jiashen tablets (JST) vs. Model group (untreated heart failure) was evaluated on Cardiac function (LVEF, LVFS, LVIDd, LVIDs, IVSd, IVSs) and plasma metabolic profiles. Jiashen tablets significantly improved cardiac function, reduced myocardial damage markers, and inhibited myocardial fibrosis in heart failure rats by restoring 29 metabolites related to amino acid and lipid metabolism.
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