Key result
NT-proBNP was a strong independent predictor of mortality (HR 5.70, p<0.0001) and hospital admissions for heart failure (HR 13.83, p<0.0001) in the general population.
Why the study?
Does plasma NT-proBNP concentration accurately diagnose systolic heart failure and predict mortality and hospital admissions in the general population?
Population
672 adults randomly selected from the general population in four age groups.
Design
Cohort
Follow-up
median 805 days
Authors
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NT-proBNP may aid risk stratification in unselected adults; leaves open prospective validation for HF diagnosis and management.
Cohort (n=672)
Yes
Does plasma NT-proBNP concentration accurately diagnose systolic heart failure and predict mortality and hospital admissions in the general population?
Effect estimate: HR 5.70
p-value: p=< 0.0001
NT-proBNP is a highly sensitive diagnostic screening tool for systolic heart failure and a strong independent predictor of mortality and cardiac admissions in the general population.
Groenning et al. (2004) conducted a cohort in Systolic heart failure (n=672). NT-proBNP measurement was evaluated on Mortality (HR 5.70, p=< 0.0001). NT-proBNP was a strong independent predictor of mortality (HR 5.70, p<0.0001) and hospital admissions for heart failure (HR 13.83, p<0.0001) in the general population.
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