Reliability of N-terminal pro-brain natriuretic peptide assay in diagnosis of heart failure: cohort study in representative and high risk community populations
Why the study?
Does the NT-proBNP assay accurately diagnose heart failure in general and high-risk community populations?
Population
591 randomly sampled patients over the age of 45, stratified for age and socioeconomic status, falling into…
Design
Cohort
Authors
Discussion
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Member takes
Implication
May aid ruling out heart failure in community settings; leaves open prospective validation before changing practice.
Structured PICO
Does the NT-proBNP assay accurately diagnose heart failure in general and high-risk community populations?
P
Population
591 randomly sampled patients over the age of 45, stratified for age and socioeconomic status, falling into four cohorts (general population, patients with an existing clinical label of heart failure, patients prescribed diuretics, and patients deemed at high risk of heart failure) from four general practices in the West Midlands of England.
I
Intervention
N-terminal pro-brain natriuretic peptide (NT-proBNP) assay
O
Outcome
Sensitivity, specificity, positive and negative predictive values, likelihood ratios, and area under receiver operating characteristic curve for NT-proBNP assay in the diagnosis of heart failuresurrogate
The NT-proBNP assay demonstrates a high negative predictive value, making it a valuable tool to rule out heart failure in community settings.
Cite This Study
Richard Hobbs (2002) studied this question.