Key result
Higher C-reactive protein to albumin ratio linked to increased LVT risk following anterior STEMI.
Why the study?
Left ventricular thrombus is linked to inflammation after anterior STEMI, but data regarding the role of the C-reactive protein to albumin ratio in LVT development are lacking.
Does the C-reactive protein to albumin ratio predict left ventricular thrombus development in patients with anterior STEMI treated percutaneously?
Cohort (n=955)
Does the C-reactive protein to albumin ratio predict left ventricular thrombus development in patients with anterior STEMI treated percutaneously?
p-value: p=<.001
The C-reactive protein to albumin ratio is significantly elevated in patients who develop left ventricular thrombus following percutaneously treated anterior STEMI, suggesting its utility as a simple predictive biomarker.
CAR was associated with post-STEMI LVT; hypothesis-generating and requires prospective validation before clinical use.
Left ventricular thrombus (LVT) is associated with inflammatory response in survivors with anterior ST-elevation myocardial infarction (STEMI). The C-reactive protein to albumin ratio (CAR) has been proposed as a marker of inflammation. However, there is a lack of data with respect to the role of CAR in LVT development. We investigated the relationship between CAR and LVT development in patients with anterior STEMI treated percutaneously; 955 consecutive patients were enrolled and LVT was observed in 126 (13.2%) patients. Clinical, demographic, and laboratory parameters were recorded. The CAR was significantly higher in patients with LVT (12.6 [8.6-16.1] vs 18.1 [11.5-23], P < .001). Other independent predictors for LVT development were lower ejection fraction, the presence of left ventricular apical aneurysm, proximal left anterior descending lesion location, glycoprotein IIb/IIIa inhibitors treatment, >1 diseased arteries, higher total protein level, neutrophil count, and peak creatine kinase myocardial band activity. In conclusion, the CAR may be useful as a simple tool for predicting LVT development among survivors of anterior STEMI.
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Çırakoğlu et al. (2020) conducted a cohort in Anterior ST-elevation myocardial infarction (STEMI) (n=955). C-reactive protein to albumin ratio (CAR) was evaluated on Left ventricular thrombus (LVT) development (p=<.001). A higher C-reactive protein to albumin ratio was significantly associated with left ventricular thrombus development following anterior STEMI (median CAR 18.1 vs 12.6; P<.001).
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