Key result
Higher admission CRP/albumin ratio linked to ~56% higher risk of impaired infarct-related artery patency in STEMI.
Why the study?
Inflammatory markers such as C-reactive protein and Albumin have been associated with poor prognosis in STEMI, but their relationship with infarct-related artery patency before primary PCI is unclear.
Observational (n=822)
Odds Ratio: 1.56 (95% CI 1.22–1.97)
p-value: p=<0.001
CAR may correlate with IRA patency in STEMI before p-PCI; hypothesis-generating and should not yet alter practice.
Background: Inflammatory markers such as C-reactive protein and Albumin have previously been associated with poor prognosis in ST-elevation myocardial infarction (STEMI). Objective: The present study aims to investigate the relationship between the infarct-related arteries (IRA) patency and C-reactive protein/Albumin ratio (CAR) before primary percutaneous intervention (p-PCI) in patients with STEMI. Methods A total of 822 patients who underwent primary PCI (p-PCI) for acute STEMI were included in this study. Patients were divided into two groups according to IRA patency as TIMI flow 0-1 (n = 551) and TIMI flow 2-3 (n = 271). CAR ratio measured at admission was compared with IRA patency. Results: The average age of 822 patients was 55±12, and 84.3% (693) of the patients were male. The mean CAR level of the patients was determined as 0.26 (0.08-0.48). CAR level was statistically significantly higher in TIMI flow 0-1 group when compared to TIMI flow 2-3 group [0.31 (0.09-0.51) vs 0.23 (0.06-0.42); p<0.001]. In the multivariate logistic regression analysis a significant relation was found between CAR (odds ratio [OR]:1.56, 95% confidence interval [CI]:1.22-1.97, p<0.001), and neutrophil count (OR:1.72, 95% CI:1.33-2.25, p<0.001) in patients with TIMI flow 0-1 Conclusion: An inflammation-based risk index, CAR measured at admission in patients with anterior STEMI has been found to be a useful prognostic tool for predicting adverse cardiovascular outcomes. However, this finding needs to be confirmed in future prospective studies.
No takes yet. Share an insight, caveat, or question.
Akın et al. (2021) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=822). C-reactive protein/Albumin ratio (CAR) was evaluated on Impaired infarct-related artery patency (TIMI flow 0-1) (OR 1.56, 95% CI 1.22-1.97, p=<0.001). Higher C-reactive protein/Albumin ratio at admission was significantly associated with impaired infarct-related artery patency (TIMI flow 0-1) in STEMI patients (OR 1.56; 95% CI 1.22-1.97; P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: