Key result
L-arginine ameliorated adverse cardiovascular effects of hypertension in aged spontaneously hypertensive rats, reducing arterial pressure, left ventricular mass, and collagen content.
Why the study?
Does L-arginine improve coronary hemodynamics and reduce cardiac fibrosis in aged spontaneously hypertensive and normotensive rats?
Population
Male 1-year-old normotensive Wistar-Kyoto rats (WKYs) and spontaneously hypertensive rats (SHR)
Comparison
L-arginine in drinking water for 6 months vs Placebo in drinking water
Design
Preclinical
Follow-up
6 months
Authors
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No immediate change to hypertension management; leaves open translation of rat findings to human trials.
Does L-arginine improve coronary hemodynamics and reduce cardiac fibrosis in aged spontaneously hypertensive and normotensive rats?
Prolonged L-arginine supplementation ameliorates the adverse cardiovascular effects of hypertension, including cardiac hypertrophy and fibrosis, in aged spontaneously hypertensive rats.
Sušić et al. (1999) studied Hypertension. L-arginine vs. Placebo was evaluated on Systemic and coronary hemodynamics, ventricular and aortic mass indexes, and ventricular hydroxyproline concentrations. L-arginine ameliorated adverse cardiovascular effects of hypertension in aged spontaneously hypertensive rats, reducing arterial pressure, left ventricular mass, and collagen content.
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